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Neurodegenerative disease

Neurodegenerative disease


Saul Yudelowitz BSc (Hons)

Neurodegenerative disease like Alzheimer’s is on the increase and despite what health care around the world say that obesity will be the single biggest cost they are wrong. While this article will give you the ability to make an informed choice about your neural health there is not enough space for an in depth review of just what one can do. We will look at some of the most important aspects for now.

Just like any muscle of the body, when we sleep the healing process takes place. A recent article on the BBC web page says that of 15500 twelve to eighteen year olds who went to bed after midnight were 24% more likely to have depression than those who went to bed at 22H00. There are many factors from sleep that contribute to the healing process. The release of a hormone called Melatonin has a significant effect. It not only is a very good antioxidant but it also sets up our circadian rhythms, which ultimately regulate the entire timing of the hormonal system. This is essential for healthy growth and repair of all tissue. It has been shown that when Cortisol levels are high, which happens when we are stimulated, naturally or with the use of anything that ends in ‘ine’ like caffeine, our brain learns from our actions what to do to survive. People who get stressed and always respond in the same way easily explain this. Another way to explain this is when one has not eaten for a long period and has therefore relied on ‘ine’. If there first meal is a fatty, sugary meal there Cortisol will teach the brain to crave this type of food, which ultimately leads to obesity. Obesity has also been shown to contribute to neurodegenerative disease.

There are other issues with any one who has long-term stimulation from stress. Weather this stress is from life like work, relationships at work and personal to anyone using ‘ine’ like using thermogenics sold to loose weight. The net result over a long period is neurodegenerative disease. This occurs because as the sympathetic drive is chronically elevated growth and repair of tissue cant occur effectively. The increase in blood pressure is not good for neural tissue, which is very sensitive to pressure. Chronic sympathetic stimulation forces the majority of the blood to the hind brain for survival and does not leave much in the cortex area. Chronic sympathetic stimulation also leads to the release of high levels of Cortisol and clotting agents in the blood making the blood more viscous. This leads to chronic low levels of inflammation, another cause of neurodegenerative despise.

The brain has a blood brain barriers (BBB) to protect it from anything in the blood. Only partials of a certain size can cross and when it crosses over it uses a transport system. Understanding this transport system is critical so that one can allow the most efficient mix of supplements to reach the brain. Alpha Lapoic Acid (ALA) is another very good antioxidant; it also has an effect on the insulin receptor making it more efficient. The vast majority of ALA is the S form, while it has a benefit for the body it does not cross the BBB and so cant affect the brain. The R for ALA can cross the BBB and so this does help protect the brain. Acetyl-L-Carnitine is a substrate for Acetylcholine, which is critical for memory; it also has a protective effect on the mitochondria of the brain. Idebenone is another very good antioxidant and once again protects the mitochondria of the brain and heart. Phosphatidylcholine, Phosphatidylserine and Citicholine are all important for cognitive function. Genistein, Allica and Silymarin inhibit excess NO in the brain, which leads to degeneration of neural tissue. While there are other supplements that should be use to reduce chronic inflammation of the brain we have not included them here. Environmental pollution is another cause of neurodegenerative disease.

Going back to the first point that we made about chronic sympathetic stimulation. When Sympathetically stimulated the Limbic and Hippocampus get involved. This chronic overstimulation of these areas and not allowing the chemicals produced from this to be dissipated leads to neurodegenerative disease. When an animal survives a near death experience like being hunted by a predator, it physically continues to move so that all excess chemicals associated with sympathetic stimulation can de dissipated. Finding a way that is healthy to burn up these excess chemicals when stressed is important.


The information contained in this Newsletter was prepared from medical and scientific sources, which are referenced and are believed to be accurate and reliable. The information herein should not be used to treat or to prevent any medical condition unless it is used with the full knowledge, compliance and agreement of your personal physician or other licensed health care professional. Readers are strongly advised to seek the advice of their personal health care professional(s) before proceeding with any changes in any health care program.

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