The human intestinal tract contains seven enzymes that split dietary disaccharides into free monosaccharides. Until now, commercially available enzyme products contained enzyme ingredients that had the activity of only some of these disaccharidase enzymes. One in particular, however, sucrase-isomaltase complex, was only partially represented in these products. Invertase is present in these products to hydrolyze sucrose to yield glucose and fructose, and to hydrolyze other complex sugars that contain fructose, so it acts as a sucrase enzyme. The isomaltase fraction of that human enzyme is not represented because there is no commercially available form of isomaltase available in the world.
The importance of this missing enzyme fraction was confirmed in January 2004 by R. Kushak, PhD and T. Buie, MD of Massachusetts General Children’s Hospital in an intestinal biopsy study involving 100 special needs children. The study showed that 60% of these patients had weak lactase activity and 25-45% had weak isomaltase/palatinase activity, which substantiated their special dietary need for an enzyme providing isomaltase/palatinase activity.
This study provided the impetus for Kirkman® to search for an enzyme that had isomaltase/palatinase activity. Kirkman® found that enzyme and trademarked it Isogest®.
Isogest® has the ability to split isomaltose into two molecules of glucose and to split palatinose into one molecule of glucose and one molecule of fructose. The result of including this new enzyme is better, more complete carbohydrate digestion. Currently, no other enzyme product can offer this added activity.
EnZym-Complete/DPP-IV™ II with Isogest® is Kirkman’s second generation version of Enzym-Complete/DPPIV™. It contains all the enzymes present in Enzym-Complete/DPPIV™ plus Isogest®. The presence of Isogest® gives this product the equivalent activity of the isomaltase fraction of the sucrase/isomaltase enzyme found in the human digestive system.
Individuals currently using Enzym-Complete/DPPIV™ who are getting partial results and still need some improvement or individuals using other enzymes who are not completely satisfied with the results should try EnZym-Complete/DPP-IV™ II with Isogest® formula.
Physicians and parents who evaluated products containing Kirkman’s Isogest® reported the following: